Open AccessPrevalence of Protease and Reverse Transcriptase Drug Resistance Mutations over Time in Drug-Naïve Human Immunodeficiency Virus Type 1-Positive Individuals in Rio de Janeiro, Brazil
Author(s) -
Ana Teresa Nogueira Dumans,
Marcelo A. Soares,
Danuta Pieniążek,
Marcia L. Kalish,
Véronique De Vroey,
Kurt Hertogs,
Amílcar Tanuri
Publication year - 2002
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.46.9.3075-3079.2002
Subject(s) - reverse transcriptase , virology , protease , drug resistance , biology , virus , protease inhibitor (pharmacology) , drug , nucleoside reverse transcriptase inhibitor , human immunodeficiency virus (hiv) , polymerase chain reaction , microbiology and biotechnology , enzyme , genetics , viral load , gene , pharmacology , antiretroviral therapy , biochemistry
The prevalence of mutations that confer resistance to protease inhibitors and to nucleoside and nonnucleoside reverse transcriptase inhibitors in 49 blood samples from drug-naïve human immunodeficiency virus type 1-infected blood donors living in Rio de Janeiro state, Brazil, in 1998 was evaluated genotypically and phenotypically.
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