Stable Concentrations of Zidovudine, Stavudine, Lamivudine, Abacavir, and Nevirapine in Serum and Cerebrospinal Fluid during 2 Years of Therapy | Zendy

Rieneke M. E. van Praag | Zendy; Elisabeth C. M. van Weert | Zendy; Rolf P. G. van Heeswijk | Zendy; XiaoJian Zhou | Zendy; JeanPierre Sommadossi | Zendy; Suzanne Jurriaans | Zendy; Joep M. A. Lange | Zendy; Richard M. W. Hoetelmans | Zendy; Jan M. Prins | Zendy

Open Access

Stable Concentrations of Zidovudine, Stavudine, Lamivudine, Abacavir, and Nevirapine in Serum and Cerebrospinal Fluid during 2 Years of Therapy

Author(s) -

Rieneke M. E. van Praag,

Elisabeth C. M. van Weert,

Rolf P. G. van Heeswijk,

XiaoJian Zhou,

JeanPierre Sommadossi,

Suzanne Jurriaans,

Joep M. A. Lange,

Richard M. W. Hoetelmans,

Jan M. Prins

Publication year - 2002

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.46.3.896-899.2002

Subject(s) - abacavir , stavudine , lamivudine , nevirapine , zidovudine , saquinavir , didanosine , medicine , virology , cerebrospinal fluid , pharmacology , ritonavir , viral load , viral disease , human immunodeficiency virus (hiv) , antiretroviral therapy , virus , hepatitis b virus

For a number of antiretroviral drugs, prolonged suppression of viral replication is related to drug exposure. Therefore, it is important to maintain stable concentrations during prolonged therapy. While studies suggest that saquinavir concentrations decrease over time, we show that concentrations of zidovudine, stavudine, lamivudine, abacavir, and nevirapine in serum and cerebrospinal fluid are stable during 2 years of therapy.

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