Open AccessIn Vitro Synergy of Caspofungin and Amphotericin B against Aspergillus and Fusarium spp
Author(s) -
Sevtap Arıkan,
Mario Lozano-Chiu,
Victor L. Paetznick,
John H. Rex
Publication year - 2002
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.46.1.245-247.2002
Subject(s) - caspofungin , antagonism , amphotericin b , microbiology and biotechnology , checkerboard , fusarium , aspergillus , in vitro , biology , fungi imperfecti , antibiotics , pharmacology , antifungal , biochemistry , botany , receptor
We investigated the in vitro interaction of caspofungin and amphotericin B for clinical isolates of Aspergillus and FUSARIUM: Synergy tests were performed using the checkerboard method and following the NCCLS M38-P guidelines in Antibiotic Medium 3 broth supplemented to 2% glucose. Antagonism was not observed for any of the isolates tested. Caspofungin and amphotericin B were synergistic or synergistic to additive for at least half of the isolates.