Open AccessEmergence of a Pneumococcal Clone with Cephalosporin Resistance and Penicillin Susceptibility
Author(s) -
Anthony M. Smith,
Roelof F. Botha,
H. J. Koornhof,
Keith P. Klugman
Publication year - 2001
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.45.9.2648-2650.2001
Subject(s) - penicillin , cephalosporin , microbiology and biotechnology , streptococcus pneumoniae , serotype , biology , clone (java method) , pneumococcal infections , antibacterial agent , antibiotics , gene , genetics
We report two South African serotype 6B pneumococcal isolates with cephalosporin resistance, yet with susceptibility to penicillin. DNA fingerprinting revealed that they were clonal in origin. pbp 2X and 1A genes showed major alterations typical of cephalosporin-resistant pneumococci. The pbp 2B gene was completely unaltered, explaining the penicillin susceptibility of the isolates.