Domestic Cat Model for Predicting Human Nucleoside Analogue Pharmacokinetics in Blood and Seminal Plasma | Zendy

Holly L. Jordan | Zendy; Arlene S. Pereira | Zendy; Myron S. Cohen | Zendy; Angela D. M. Kashuba | Zendy

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Domestic Cat Model for Predicting Human Nucleoside Analogue Pharmacokinetics in Blood and Seminal Plasma

Author(s) -

Holly L. Jordan,

Arlene S. Pereira,

Myron S. Cohen,

Angela D. M. Kashuba

Publication year - 2001

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.45.7.2173-2176.2001

Subject(s) - pharmacokinetics , lamivudine , zidovudine , semen , nucleoside , pharmacology , cats , nucleoside analogue , blood plasma , in vivo , biology , virology , medicine , human immunodeficiency virus (hiv) , endocrinology , viral disease , virus , biochemistry , hepatitis b virus , genetics , microbiology and biotechnology

To establish whether a feline model can predict nucleoside analogue behavior in human semen, zidovudine (ZDV) and lamivudine (3TC) pharmacokinetic parameters (PKs) were determined in the blood and seminal plasma of healthy cats. Our results show considerable similarity in ZDV and 3TC PKs between cats and humans. As in humans, ZDV and 3TC tend to accumulate in feline seminal plasma. Area under the blood plasma concentration-time curve was predictive of seminal plasma excretion. The felid model offers a unique in vivo experimental alternative for investigating the pharmacokinetics of nucleoside analogues in the male genital tract.

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