Open AccessPrevention and Treatment of Lethal Murine Endotoxemia by the Novel Immunomodulatory Agent MFP-14
Author(s) -
Ferdinando Nicoletti,
Roberto Di Marco,
Paola Sacerdote,
Pier Luigi Meroni,
Katia Mangano,
Carl K. Edwards,
A Bartorelli,
Klaus Bendtzen,
Alberto E. Panerai
Publication year - 2001
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.45.5.1591-1594.2001
Subject(s) - lipopolysaccharide , tumor necrosis factor alpha , sepsis , pathogenesis , lethality , immunology , interferon gamma , alpha (finance) , cytokine , pharmacology , medicine , biology , toxicology , construct validity , nursing , patient satisfaction
Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.