Open AccessBlocking the Receptor for Interleukin 10 Protects Mice from Lethal Listeriosis
Author(s) -
Regina Silva,
Rui Appelberg
Publication year - 2001
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.45.4.1312-1314.2001
Subject(s) - listeria monocytogenes , monoclonal antibody , receptor , blocking (statistics) , microbiology and biotechnology , listeria , bacteria , blocking antibody , biology , interleukin 2 , interleukin , immunology , antibody , cytokine , biochemistry , statistics , genetics , mathematics
High doses of Listeria monocytogenes overcome the ability of a normal mouse to control the infection, due to massive bacterial replication. Treatment with an anti-interleukin 10 (IL-10) receptor monoclonal antibody prevented the fatal course of infection with high doses of bacteria. This work shows that blocking the receptor for IL-10 may have useful therapeutic applications.