Open AccessHigh-Dose Intravenous Ribavirin Therapy for Subacute Sclerosing Panencephalitis
Author(s) -
Mitsuaki Hosoya,
Shirô Shigeta,
Shuichi Mori,
Akemi Tomoda,
Seiji Shiraishi,
Teruhisa Miike,
Hitoshi Suzuki
Publication year - 2001
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.45.3.943-945.2001
Subject(s) - subacute sclerosing panencephalitis , ribavirin , medicine , cerebrospinal fluid , virology , in vivo , virus , pathology , immunology , measles virus , biology , measles , hepatitis c virus , microbiology and biotechnology , vaccination
Two patients with subacute sclerosing panencephalitis (SSPE) were treated safely and effectively with high doses of intravenous ribavirin combined with intraventricular alpha interferon. The ribavirin concentrations maintained in the serum and cerebrospinal fluid were higher than those which inhibit SSPE virus replication in vitro and in vivo.
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