Open AccessIn Vitro Antibacterial Activities of AF 3013, the Active Metabolite of Prulifloxacin, against Nosocomial and Community Italian Isolates
Author(s) -
Maria Pia Montanari,
Marina Mingoia,
Pietro E. Varaldo
Publication year - 2001
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.45.12.3616-3622.2001
Subject(s) - ciprofloxacin , minimum inhibitory concentration , active metabolite , metabolite , microbiology and biotechnology , bacteria , minimum bactericidal concentration , in vitro , antibiotics , biology , chemistry , biochemistry , genetics
AF 3013, the active metabolite of prulifloxacin, was tested to determine its inhibitory and bactericidal activities against 396 nosocomial and 258 community Italian isolates. Compared with that of ciprofloxacin, its activity (assessed in MIC and minimal bactericidal concentration tests) was generally similar or greater against gram-positive bacteria and greater against gram-negative bacteria. In time-kill assays using selected isolates, its bactericidal activity was comparable to that of ciprofloxacin.