Postantibiotic Effects and Bactericidal Activities of Clarithromycin–14-Hydroxy-Clarithromycin, versus Those of Amoxicillin-Clavulanate, against Anaerobes | Zendy

Rose Jung | Zendy; Chad R. Messick | Zendy; Susan L. Pendland | Zendy; Eljim P. Tesoro | Zendy; Karen J. Losendahl | Zendy; Christopher Schriever | Zendy; Larry H. Danziger | Zendy

Open Access

Postantibiotic Effects and Bactericidal Activities of Clarithromycin–14-Hydroxy-Clarithromycin, versus Those of Amoxicillin-Clavulanate, against Anaerobes

Author(s) -

Rose Jung,

Chad R. Messick,

Susan L. Pendland,

Eljim P. Tesoro,

Karen J. Losendahl,

Christopher Schriever,

Larry H. Danziger

Publication year - 2000

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.44.3.778-779.2000

Subject(s) - clarithromycin , bacteroides fragilis , microbiology and biotechnology , amoxicillin , peptostreptococcus , antibacterial agent , bacteroides , antibiotics , biology , bacteria , genetics

The bactericidal activities and postantibiotic effects (PAE) of clarithromycin-14-hydroxy-clarithromycin and amoxicillin-clavulanate against Bacteroides fragilis and Peptostreptococcus anaerobius were determined. A concentration of twice the MIC resulted in bactericidal activity against four of four and three of four organisms at 24 h with clarithromycin-14-hydroxy-clarithromycin and amoxicillin-clavulanate, respectively. The PAE of clarithromycin-14-hydroxy-clarithromycin was 1.44 to 3.20 h, compared to the less than 1 h of amoxicillin-clavulanate. Clarithromycin-14-hydroxy-clarithromycin possesses good activity against susceptible anaerobes.

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