Open AccessPulsed Ultrasound Enhances the Killing of Escherichia coli Biofilms by Aminoglycoside Antibiotics In Vivo
Author(s) -
Andrea M. Rediske,
Beverly L. Roeder,
Jared L. Nelson,
Rachel L. Robison,
G. Bruce Schaalje,
Richard A. Robison,
William G. Pitt
Publication year - 2000
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.44.3.771-772.2000
Subject(s) - aminoglycoside , gentamicin , escherichia coli , in vivo , microbiology and biotechnology , antibiotics , biofilm , bacteria , ultrasound , chemistry , biology , medicine , biochemistry , genetics , radiology , gene
Escherichia coli biofilms on two polyethylene disks were implanted subcutaneously into rabbits receiving systemic gentamicin. Ultrasound was applied for 24 h to one disk. Both disks were removed, and viable bacteria were counted. Pulsed ultrasound significantly reduced bacterial viability below that of nontreated biofilms without damage to the skin.