The Macrolide-Lincosamide-Streptogramin B Resistance Determinant from Clostridium difficile 630 Contains Two erm (B) Genes | Zendy

Kylie A. Farrow | Zendy; Dena Lyras | Zendy; Julian I. Rood | Zendy

Open Access

The Macrolide-Lincosamide-Streptogramin B Resistance Determinant from Clostridium difficile 630 Contains Two erm (B) Genes

Author(s) -

Kylie A. Farrow,

Dena Lyras,

Julian I. Rood

Publication year - 2000

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.44.2.411-413.2000

Subject(s) - clostridium difficile , lincosamides , clostridium perfringens , biology , microbiology and biotechnology , gene , genetics , clostridium difficile toxin b , clostridium difficile toxin a , bacteria , antibiotic resistance , antibiotics

The ErmB macrolide-lincosamide-streptogramin B (MLS) resistance determinant from Clostridium difficile 630 contains two copies of an erm(B) gene, separated by a 1.34-kb direct repeat also found in an Erm(B) determinant from Clostridium perfringens. In addition, both erm(B) genes are flanked by variants of the direct repeat sequence. This genetic arrangement is novel for an ErmB MLS resistance determinant.

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