In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium falciparum | Zendy

Michel Frédérich | Zendy; MariePierre Hayette | Zendy; Monique Tits | Zendy; Patrick De Mol | Zendy; Luc Angenot | Zendy

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In Vitro Activities of Strychnos Alkaloids and Extracts against Plasmodium falciparum

Author(s) -

Michel Frédérich,

MariePierre Hayette,

Monique Tits,

Patrick De Mol,

Luc Angenot

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.9.2328

Subject(s) - plasmodium falciparum , chloroquine , in vitro , alkaloid , strain (injury) , biology , pharmacology , traditional medicine , microbiology and biotechnology , chemistry , malaria , biochemistry , medicine , botany , immunology , anatomy

The in vitro antimalarial activities of 46 alkaloids and extracts from Strychnos species were evaluated. Two types of quasidimeric alkaloids exhibit high and selective activities against Plasmodium. Strychnopentamine and isostrychnopentamine were active against chloroquine-sensitive and -resistant strains (50% inhibitory concentration [IC(50)] approximately 0.15 microM), while dihydrousambarensine exhibited a 30-fold higher activity against the chloroquine-resistant strain (IC(50) = 0.03 microM) than it did against the chloroquine-sensitive strain.

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