Mononuclear and Polymorphonuclear Leukocyte Dispositions of Clarithromycin and Azithromycin in AIDS Patients Requiring Mycobacterium avium Complex Prophylaxis | Zendy

Khanh Q. Bui | Zendy; JoCarol McNabb | Zendy; Chonghua Li | Zendy; Charles H. Nightingale | Zendy; David P. Nicolau | Zendy

Open Access

Mononuclear and Polymorphonuclear Leukocyte Dispositions of Clarithromycin and Azithromycin in AIDS Patients Requiring Mycobacterium avium Complex Prophylaxis

Author(s) -

Khanh Q. Bui,

JoCarol McNabb,

Chonghua Li,

Charles H. Nightingale,

David P. Nicolau

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.9.2302

Subject(s) - clarithromycin , azithromycin , peripheral blood mononuclear cell , medicine , mycobacterium avium intracellulare infection , mycobacterium , mycobacterium avium complex , antibacterial agent , intracellular , microbiology and biotechnology , dosing , immunology , antibiotics , biology , pharmacology , pathology , tuberculosis , in vitro , biochemistry

The intracellular dispositions of clarithromycin and azithromycin in AIDS patients requiring Mycobacterium avium complex (MAC) prophylaxis were studied. The dispositions of both drugs in mononuclear and polymorphonuclear leukocytes were markedly different. Our data support the proven efficacy of these agents for MAC prophylaxis since clarithromycin and azithromycin displayed sustained intracellular concentrations which exceeded their MICs for MAC throughout the dosing periods.

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