In Vitro Activities of Fluoroquinolones against Antibiotic-Resistant Blood Culture Isolates of Viridans Group Streptococci from across Canada | Zendy

Joyce C. S. de Azavedo | Zendy; Lilyanna Trpeski | Zendy; Sylvia Pong-Porter | Zendy; S. O. Matsumura | Zendy; Donald E. Low | Zendy

Open Access

In Vitro Activities of Fluoroquinolones against Antibiotic-Resistant Blood Culture Isolates of Viridans Group Streptococci from across Canada

Author(s) -

Joyce C. S. de Azavedo,

Lilyanna Trpeski,

Sylvia Pong-Porter,

S. O. Matsumura,

Donald E. Low

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.9.2299

Subject(s) - microbiology and biotechnology , gatifloxacin , viridans streptococci , ciprofloxacin , penicillin , streptococcus pneumoniae , tetracycline , erythromycin , streptococcus mitis , antibiotics , streptococcus , trovafloxacin , blood culture , streptococcaceae , trimethoprim , biology , sulfamethoxazole , bacteria , genetics

Among 418 blood culture isolates of viridans group streptococci obtained between 1995 and 1997, the in vitro rates of nonsusceptibility to penicillin, erythromycin, tetracycline, and trimethoprim-sulfamethoxazole were 28, 29, 24, and 14%, respectively. The most prevalent group (125 strains) was Streptococcus mitis, followed by Streptococcus sanguis (56 strains). For 236 (56%) strains resistant to one or more antibiotics, the ciprofloxacin MIC at which 90% of the isolates were inhibited (MIC(90)) was 4 microg/ml, whereas the MIC(90)s of trovafloxacin, grepafloxacin, and gatifloxacin were 0.25 microg/ml.

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