Inhibition ofEscherichia coli-Induced Meningitis by Carboxyfullerence | Zendy

Nina Tsao | Zendy; Puthuparampil P. Kanakamma | Zendy; TienYau Luh | Zendy; ChenKung Chou | Zendy; HuanYao Lei | Zendy

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Inhibition ofEscherichia coli-Induced Meningitis by Carboxyfullerence

Author(s) -

Nina Tsao,

Puthuparampil P. Kanakamma,

TienYau Luh,

ChenKung Chou,

HuanYao Lei

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.9.2273

Subject(s) - escherichia coli , meningitis , microbiology and biotechnology , tumor necrosis factor alpha , blood–brain barrier , infiltration (hvac) , enterobacteriaceae , interleukin , biology , pharmacology , chemistry , cytokine , immunology , medicine , biochemistry , central nervous system , endocrinology , gene , physics , thermodynamics , psychiatry

The effect of a water-soluble malonic acid derivative of carboxyfullerence (C60) against Escherichia coli-induced meningitis was tested. C60 can protect the mice from E. coli-induced death in a dose-dependent manner. C60 administered intraperitoneally as late as 9 h after E. coli injection was still protective. The C60-treated mice had less tumor necrosis factor alpha and interleukin-1beta production by staining of brain tissue compared to the levels of production for nontreated mice. The E. coli-induced increases in blood-brain barrier permeability and inflammatory neutrophilic infiltration were also inhibited. These data suggest that C60 is a potentially therapeutic agent for bacterial meningitis.

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