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In Vitro Activities of Polycationic Peptides Alone and in Combination with Clinically Used Antimicrobial Agents against Rhodococcus equi
Author(s) -
Andrea Giacometti,
Oscar Cirioni,
F. Ancarani,
Maria Simona Del Prete,
M. Fortuna,
Giorgio Scalise
Publication year - 1999
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.43.8.2093
Subject(s) - rhodococcus equi , antimicrobial , nisin , microbiology and biotechnology , clarithromycin , vancomycin , magainin , ampicillin , linezolid , rifabutin , antibiotics , biology , in vitro , bacteria , antimicrobial peptides , staphylococcus aureus , biochemistry , genetics , virulence , gene
The in vitro activities of magainin II, nisin, and ranalexin alone and in combination with other antimicrobial agents against six clinical isolates of Rhodococcus equi were investigated by MIC and time-kill studies. All isolates were more susceptible to nisin. A positive interaction was observed when the peptides were combined with ampicillin, ceftriaxone, rifabutin, rifampin, azithromycin, clarithromycin, and vancomycin.

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