Contribution of kasA Analysis to Detection of Isoniazid-Resistant Mycobacterium tuberculosis in Singapore | Zendy

Ann S. G. Lee | Zendy; Irene H. K. Lim | Zendy; Lynn L. H. Tang | Zendy; Amalio Telenti | Zendy; Sin Yew Wong | Zendy

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Contribution of kasA Analysis to Detection of Isoniazid-Resistant Mycobacterium tuberculosis in Singapore

Author(s) -

Ann S. G. Lee,

Irene H. K. Lim,

Lynn L. H. Tang,

Amalio Telenti,

Sin Yew Wong

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.8.2087

Subject(s) - isoniazid , mycobacterium tuberculosis , genotype , microbiology and biotechnology , mycobacterium , tuberculosis , biology , gene , medicine , genetics , pathology

Genotypic analysis of resistance to isoniazid (INH) in Mycobacterium tuberculosis is complex due to the various genes potentially involved. Mutations in ketoacyl acyl carrier protein synthase (encoded by kasA) were present in 16 of 160 (10%) INH-resistant isolates (R121K [n = 1], G269S [n = 3], G312S [n = 11], G387D [n = 1]). However, G312S was also present in 6 of 32 (19%) susceptible strains. kasA analysis contributed marginally to the performance of INH genotypic testing in Singapore. The significance of kasA polymorphisms in INH resistance should be carefully established.

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