Role of Permeability in the Activities of β-Lactams against Gram-Negative Bacteria Which Produce a Group 3 β-Lactamase | Zendy

Naoki Matsumura | Zendy; Shinzaburo Minami | Zendy; Yasuo Watanabe | Zendy; Shizuko Iyobe | Zendy; Susumu Mitsuhashi | Zendy

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Role of Permeability in the Activities of β-Lactams against Gram-Negative Bacteria Which Produce a Group 3 β-Lactamase

Author(s) -

Naoki Matsumura,

Shinzaburo Minami,

Yasuo Watanabe,

Shizuko Iyobe,

Susumu Mitsuhashi

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.8.2084

Subject(s) - cefpirome , ceftazidime , meropenem , piperacillin , imipenem , microbiology and biotechnology , beta lactamase , chemistry , antibiotics , biology , bacteria , escherichia coli , biochemistry , antibiotic resistance , genetics , gene , pseudomonas aeruginosa

The production of a group 3 β-lactamase permittedEscherichia coli to raise the MICs of ceftazidime, cefpirome, and meropenem greatly but those of imipenem and piperacillin only slightly. The ratios of maximum rate of hydrolysis toKm of ceftazidime, cefpirome, and piperacillin were lower than those of meropenem and imipenem for the group 3 β-lactamase. The permeability coefficients for piperacillin and meropenem were higher than those for ceftazidime and cefpirome. Imipenem had the highest permeability coefficient.

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