In Vitro and In Vivo Activities of Tea Catechins against Helicobacter pylori | Zendy

Katsuhiro Mabe | Zendy; Masami Yamada | Zendy; Itaro Oguni | Zendy; Tsuneo Takahashi | Zendy

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In Vitro and In Vivo Activities of Tea Catechins against Helicobacter pylori

Author(s) -

Katsuhiro Mabe,

Masami Yamada,

Itaro Oguni,

Tsuneo Takahashi

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.7.1788

Subject(s) - catechin , helicobacter pylori , in vivo , in vitro , gallate , chemistry , microbiology and biotechnology , epigallocatechin gallate , polyphenol , pharmacology , biology , biochemistry , antioxidant , genetics

The catechin epigallocatechin gallate showed the strongest activity of the six tea catechins tested against Helicobacter pylori (MIC for 50% of the strains tested, 8 microg/ml). It had bactericidal activity at pH 7 but not at pH </=5.0. In infected Mongolian gerbils, H. pylori was eradicated in 10 to 36% of the catechin-treated animals, with significant decreases in mucosal hemorrhage and erosion. Tea catechins, therefore, may have therapeutic effects on H. pylori infection.

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