Activation of the 2′- N -Acetyltransferase Gene [ aac ( 2′ )- Ia ] in Providencia stuartii by an Interaction of AarP with the Promoter Region | Zendy

David R. Macinga | Zendy; Michael R. Paradise | Zendy; M M Parojcic | Zendy; Philip N. Rather | Zendy

Open Access

Activation of the 2′- N -Acetyltransferase Gene [ aac ( 2′ )- Ia ] in Providencia stuartii by an Interaction of AarP with the Promoter Region

Author(s) -

David R. Macinga,

Michael R. Paradise,

M M Parojcic,

Philip N. Rather

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.7.1769

Subject(s) - providencia , acetyltransferase , gene , activator (genetics) , biology , genetics , chloramphenicol acetyltransferase , gene product , promoter , gene expression , escherichia coli , enterobacteriaceae , acetylation

Theaac (2′ )-Ia gene inProvidencia stuartii encodes a 2′-N -acetyltransferase capable of acetylating both peptidoglycan and certain aminoglycoside antibiotics. Regulation of theaac (2′ )-Ia gene is influenced in a positive manner by the product of theaarP gene, which encodes a small transcriptional activator of the AraC (XylS) family. In this study, we demonstrate the sequence requirements at theaac (2′ )-Ia promoter for AarP binding and activation.

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