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Theaac (2′ )-Ia gene inProvidencia stuartii encodes a 2′-N -acetyltransferase capable of acetylating both peptidoglycan and certain aminoglycoside antibiotics. Regulation of theaac (2′ )-Ia gene is influenced in a positive manner by the product of theaarP gene, which encodes a small transcriptional activator of the AraC (XylS) family. In this study, we demonstrate the sequence requirements at theaac (2′ )-Ia promoter for AarP binding and activation.

antimicrobial agents and chemotherapy

Activation of the 2′- N -Acetyltransferase Gene [ aac ( 2′ )- Ia ] in Providencia stuartii by an Interaction of AarP with the Promoter Region