Effect of Fluoroquinolone Concentration on Selection of Resistant Mutants of Mycobacterium bovis BCG and Staphylococcus aureus | Zendy

Yuzhi Dong | Zendy; Xilin Zhao | Zendy; John M. Domagala | Zendy; Karl Drlica | Zendy

Open Access

Effect of Fluoroquinolone Concentration on Selection of Resistant Mutants of Mycobacterium bovis BCG and Staphylococcus aureus

Author(s) -

Yuzhi Dong,

Xilin Zhao,

John M. Domagala,

Karl Drlica

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.7.1756

Subject(s) - staphylococcus aureus , microbiology and biotechnology , mycobacterium bovis , mutant , agar , agar plate , mycobacterium , biology , chemistry , bacteria , mycobacterium tuberculosis , medicine , tuberculosis , biochemistry , genetics , pathology , gene

When Mycobacterium bovis BCG and Staphylococcus aureus were plated on agar containing increasing concentrations of fluoroquinolone, colony numbers exhibited a sharp drop, followed by a plateau and a second sharp drop. The plateau region correlated with the presence of first-step resistant mutants. Mutants were not recovered at concentrations above those required for the second sharp drop, thereby defining a mutant prevention concentration (MPC). A C-8-methoxy group lowered the MPC for an N-1-cyclopropyl fluoroquinolone.

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