Rifampin and Rifabutin Resistance Mechanism in Helicobacter pylori | Zendy

M. Heep | Zendy; Daniela Beck | Zendy; E. Bayerdörffer | Zendy; Norbert Lehn | Zendy

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Rifampin and Rifabutin Resistance Mechanism in Helicobacter pylori

Author(s) -

M. Heep,

Daniela Beck,

E. Bayerdörffer,

Norbert Lehn

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.6.1497

Subject(s) - rifabutin , rpob , microbiology and biotechnology , helicobacter pylori , mycobacterium tuberculosis , rifampicin , biology , antibacterial agent , escherichia coli , antibiotics , bacteria , gene , tuberculosis , genetics , clarithromycin , medicine , 16s ribosomal rna , pathology

Eighty-one clinical isolates ofHelicobacter pylori showed no resistance to rifampin (MIC range, 0.032 to 2 μg/ml; MIC at which 50% of isolates are inhibited [MIC50 ], 0.25 μg/ml). The MIC50 of rifabutin was 0.008 μg/ml (n = 16). All resistant laboratory mutants ofH. pylori ATCC 43504 showed amino acid exchanges in codons 524 to 545 or codon 585 of therpoB gene, corresponding to the gene sequences fromMycobacterium tuberculosis andEscherichia coli.

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