Activity of Gatifloxacin Compared to Those of Five Other Quinolones versus Aerobic and Anaerobic Isolates from Skin and Soft Tissue Samples of Human and Animal Bite Wound Infections | Zendy

Ellie J. C. Goldstein | Zendy; Diane M. Citron | Zendy; C. Vreni Merriam | Zendy; Kerin L. Tyrrell | Zendy; Yumi A. Warren | Zendy

Open Access

Activity of Gatifloxacin Compared to Those of Five Other Quinolones versus Aerobic and Anaerobic Isolates from Skin and Soft Tissue Samples of Human and Animal Bite Wound Infections

Author(s) -

Ellie J. C. Goldstein,

Diane M. Citron,

C. Vreni Merriam,

Kerin L. Tyrrell,

Yumi A. Warren

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.6.1475

Subject(s) - gatifloxacin , anaerobic exercise , microbiology and biotechnology , soft tissue , human skin , antibacterial agent , medicine , antibiotics , biology , surgery , ciprofloxacin , physiology , genetics

The activity of gatifloxacin against 308 aerobes and 112 anaerobes isolated from bite wound infections was studied. Gatifloxacin was active at </=0.016 microg/ml against all 148 Pasteurella isolates (eight species and three subspecies) tested and all other aerobes tested, including Actinobacillus-Haemophilus spp., Eikenella corrodens, Neisseria weaveri, Weeksella zoohelcum, staphylococci, and streptococci. Fusobacteria were sometimes resistant. Gatifloxacin MICs at which 90% of the isolates were inhibited were 0. 125 microg/ml against Bacteroides tectum and Prevotella spp., 0.25 microg/ml against Porphyromonas spp., and 0.5 microg/ml against peptostreptococci.

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