Open AccessSynergistic In Vitro Antimalarial Activity of Omeprazole and Quinine
Author(s) -
Tina S. SkinnerAdams,
Timothy M. E. Davis
Publication year - 1999
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.43.5.1304
Subject(s) - quinine , omeprazole , in vitro , plasmodium falciparum , pharmacology , malaria , chemistry , medicine , immunology , biochemistry
Previous studies have shown that the proton pump inhibitor omeprazole has antimalarial activity in vitro. The interactions of omeprazole with commonly used antimalarial drugs were assessed in vitro. Omeprazole and quinine combinations were synergistic; however, chloroquine and omeprazole combinations were antagonistic. Artemisinin drugs had additive antimalarial activities with omeprazole.
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