In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs | Zendy

Murat Akova | Zendy; Deniz Gür | Zendy; David M. Livermore | Zendy; Tanıl Kocagöz | Zendy; Halis Akalın | Zendy

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In Vitro Activities of Antibiotics Alone and in Combination against Brucella melitensis at Neutral and Acidic pHs

Author(s) -

Murat Akova,

Deniz Gür,

David M. Livermore,

Tanıl Kocagöz,

Halis Akalın

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.5.1298

Subject(s) - brucella melitensis , doxycycline , streptomycin , azithromycin , microbiology and biotechnology , antibiotics , ofloxacin , brucella , brucellosis , chemistry , brucellaceae , antibacterial agent , pharmacology , biology , virology , ciprofloxacin

Brucellae survive acidic pHs in phagolysosomes. Azithromycin, streptomycin, and quinolones were active against Brucella melitensis at pH 7.0 but not at pH 5.0; rifampin and doxycycline retained activity at pH 5.0. Regardless of pH, azithromycin-rifampin and ofloxacin-rifampin showed less synergy than established streptomycin-doxycycline and rifampin-doxycycline combinations.

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