N-Acylated and d Enantiomer Derivatives of a Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial Activity | Zendy

Hiroyuki Wakabayashi | Zendy; Hiroshi Matsumoto | Zendy; Koichi Hashimoto | Zendy; Susumu Teraguchi | Zendy; Mitsunori Takase | Zendy; Hirotoshi Hayasawa | Zendy

Open Access

N-Acylated and d Enantiomer Derivatives of a Nonamer Core Peptide of Lactoferricin B Showing Improved Antimicrobial Activity

Author(s) -

Hiroyuki Wakabayashi,

Hiroshi Matsumoto,

Koichi Hashimoto,

Susumu Teraguchi,

Mitsunori Takase,

Hirotoshi Hayasawa

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.5.1267

Subject(s) - antimicrobial , peptide , enantiomer , chemistry , stereochemistry , biochemistry , organic chemistry

N-acylated or D enantiomer peptide derivatives based on the sequence RRWQWRMKK in lactoferricin B demonstrated antimicrobial activities greater than those of lactoferricin B against bacteria and fungi. The most potent peptide, conjugated with an 11-carbon-chain acyl group, showed two to eight times lower MIC than lactoferricin B.

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