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In Vitro Susceptibilities of Clinical Yeast Isolates to the New Antifungal Eberconazole Compared with Their Susceptibilities to Clotrimazole and Ketoconazole
Author(s) -
Josep M. Torres-Rodrı́guez,
R Méndez,
Olga López-Jodra,
Yolanda Morera,
Mateu Espasa,
Teresa Jiménez,
Carme Lagunas
Publication year - 1999
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.43.5.1258
Subject(s) - clotrimazole , ketoconazole , candida krusei , microbiology and biotechnology , biology , antifungal , antifungal drugs , cryptococcus neoformans , candida glabrata , miconazole , fluconazole
The antifungal activity of eberconazole, a new imidazole derivative, against 124 clinical isolates of Candida comprising eight different species and to 34 isolates of Cryptococcus neoformans was compared to those of clotrimazole and ketoconazole. MICs of eberconazole, determined by the National Committee for Clinical Laboratory Standards standardized microbroth method, were equal to or lower than those of other azoles, especially for Candida krusei and Candida glabrata, which are usually resistant to triazoles.

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