The Anti-Influenza Virus Drug Rimantadine Has Trypanocidal Activity | Zendy

John M. Kelly | Zendy; Michael A. Miles | Zendy; Anita C. Skinner | Zendy

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The Anti-Influenza Virus Drug Rimantadine Has Trypanocidal Activity

Author(s) -

John M. Kelly,

Michael A. Miles,

Anita C. Skinner

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.4.985

Subject(s) - rimantadine , trypanosoma brucei , trypanosoma cruzi , virology , drug , biology , influenza a virus , trypanosoma , trypanocidal agent , virus , orthomyxoviridae , microbiology and biotechnology , chemistry , pharmacology , biochemistry , parasite hosting , world wide web , computer science , gene

We report here that bloodstream forms of the African trypanosome, Trypanosoma brucei, are sensitive to the anti-influenza virus drug rimantadine (50% inhibitory concentration of 1.26 micrograms ml-1 at pH 7.4). The activity is pH dependent and is consistent with a mechanism involving inhibition of the ability to regulate internal pH. Rimantadine is also toxic to the trypanosomatid parasites Trypanosoma cruzi and Leishmania major.

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