Effect of 3-Hydroxyphthaloyl-β-Lactoglobulin on Vaginal Transmission of Simian Immunodeficiency Virus in Rhesus Monkeys | Zendy

Michael S. Wyand | Zendy; Kelledy Manson | Zendy; Christopher J. Miller | Zendy; A. R. Neurath | Zendy

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Effect of 3-Hydroxyphthaloyl-β-Lactoglobulin on Vaginal Transmission of Simian Immunodeficiency Virus in Rhesus Monkeys

Author(s) -

Michael S. Wyand,

Kelledy Manson,

Christopher J. Miller,

A. R. Neurath

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.4.978

Subject(s) - simian immunodeficiency virus , virology , simian , virus , transmission (telecommunications) , biology , immunology , herpes simplex virus , chlamydia trachomatis , electrical engineering , engineering

Heterosexual transmission of human immunodeficiency virus type 1 (HIV-1) is the major cause of the ongoing AIDS epidemic. Application of chemical barrier methods is expected to contribute to the worldwide control of this epidemic. Bovine beta-lactoglobulin modified by 3-hydroxyphthalic anhydride (3-hydroxyphthalovyl-beta-lactoglobulin [3HP-beta-LG]) was shown to inhibit HIV-1, HIV-2, simian immunodeficiency virus (SIV), herpes simplex virus type 1 and 2, and Chlamydia trachomatis infection in vitro. Here, we show that 3HP-beta-LG not formulated into any vehicle protected three of six rhesus monkeys against vaginal infection by SIV. Incorporation of the compound into an appropriate vehicle is expected to increase the degree of protection. 3HP-beta-LG may be effective as a vaginal inhibitor of HIV-1 infection in humans.

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