Mutations in the gyrA , parC , and parE Genes Associated with Fluoroquinolone Resistance in Clinical Isolates of Mycoplasma hominis | Zendy

Cécile Bébéar | Zendy; Joël Renaudin | Zendy; Alain Charron | Zendy; H. Renaudin | Zendy; Bertille de Barbeyrac | Zendy; Thierry Schaeverbeke | Zendy

Open Access

Mutations in the gyrA , parC , and parE Genes Associated with Fluoroquinolone Resistance in Clinical Isolates of Mycoplasma hominis

Author(s) -

Cécile Bébéar,

Joël Renaudin,

Alain Charron,

H. Renaudin,

Bertille de Barbeyrac,

Thierry Schaeverbeke

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.4.954

Subject(s) - biology , mycoplasma hominis , microbiology and biotechnology , virology , mycoplasmataceae , gene , mycoplasma , genetics , mollicutes

Five clinical isolates of Mycoplasma hominis from three different patients were examined for resistance to fluoroquinolones; some of these isolates were probably identical. All five isolates harbored amino acid substitutions in the quinolone resistance-determining regions of both DNA gyrase (GyrA) and topoisomerase IV (ParC or ParE). Furthermore, the novobiocin MIC for three isolates showed a significant increase. This is the first characterization of fluoroquinolone-resistant clinical mycoplasma isolates from humans.

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