Development of Resistance during Antimicrobial Therapy Caused by Insertion Sequence Interruption of Porin Genes | Zendy

Santiago Hernández-Allés | Zendy; Vicente J. Benedí | Zendy; Luis MartínezMartínez | Zendy; Álvaro Pascual | Zendy; Alicia Aguilar | Zendy; Juan M. Tomás | Zendy; Sebastián Albertí | Zendy

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Development of Resistance during Antimicrobial Therapy Caused by Insertion Sequence Interruption of Porin Genes

Author(s) -

Santiago Hernández-Allés,

Vicente J. Benedí,

Luis MartínezMartínez,

Álvaro Pascual,

Alicia Aguilar,

Juan M. Tomás,

Sebastián Albertí

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.4.937

Subject(s) - porin , cefoxitin , klebsiella pneumoniae , gene , sequence (biology) , mutation , microbiology and biotechnology , biology , escherichia coli , genetics , bacteria , staphylococcus aureus , bacterial outer membrane

We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene.

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