Molecular Characterization of an Antibiotic Resistance Gene Cluster of Salmonella typhimurium DT104 | Zendy

Connie Briggs | Zendy; Pina M. Fratamico | Zendy

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Molecular Characterization of an Antibiotic Resistance Gene Cluster of Salmonella typhimurium DT104

Author(s) -

Connie Briggs,

Pina M. Fratamico

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.4.846

Subject(s) - biology , tetracycline , plasmid , microbiology and biotechnology , gene , salmonella , antibiotic resistance , genetics , chloramphenicol , integron , streptomycin , antibiotics , bacteria

Salmonella typhimurium phage type DT104 has become an important emerging pathogen. Isolates of this phage type often possess resistance to ampicillin, chloramphenicol, streptomycin, sulfonamides, and tetracycline (ACSSuT resistance). The mechanism by which DT104 has accumulated resistance genes is of interest, since these genes interfere with treatment of DT104 infections and might be horizontally transferred to other bacteria, even to unrelated organisms. Previously, several laboratories have shown that the antibiotic resistance genes of DT104 are chromosomally encoded and involve integrons. The antibiotic resistance genes conferring the ACSSuT-resistant phenotype have been cloned and sequenced. These genes are grouped within two district integrons and intervening plasmid-derived sequences. This sequence is potentially useful for detection of multiresistant DT104.

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