Amphotericin B- and Fluconazole-Resistant Candida spp., Aspergillus fumigatus , and Other Newly Emerging Pathogenic Fungi Are Susceptible to Basic Antifungal Peptides | Zendy

Eva J. Helmerhorst | Zendy; Ingrid M. Reijnders | Zendy; Wim van ‘t Hof | Zendy; Ina M. Simoons-Smit | Zendy; Enno C.I. Veerman | Zendy; Arie V. Nieuw Amerongen | Zendy

Open Access

Amphotericin B- and Fluconazole-Resistant Candida spp., Aspergillus fumigatus , and Other Newly Emerging Pathogenic Fungi Are Susceptible to Basic Antifungal Peptides

Author(s) -

Eva J. Helmerhorst,

Ingrid M. Reijnders,

Wim van ‘t Hof,

Ina M. Simoons-Smit,

Enno C.I. Veerman,

Arie V. Nieuw Amerongen

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.3.702

Subject(s) - candida krusei , aspergillus fumigatus , candida glabrata , fluconazole , microbiology and biotechnology , candida albicans , amphotericin b , biology , aspergillus , fungi imperfecti , antifungal

The present study shows that a number of basic antifungal peptides, including human salivary histatin 5, a designed histatin analog designated dhvar4, and a peptide from frog skin, PGLa, are active against amphotericin B-resistant Candida albicans, Candida krusei, and Aspergillus fumigatus strains and against a fluconazole-resistant Candida glabrata isolate.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research