Fosfomycin Alters Lipopolysaccharide-Induced Inflammatory Cytokine Production in Mice | Zendy

Tetsuya Matsumoto | Zendy; Kazuhiro Tateda | Zendy; Shuichi Miyazaki | Zendy; Nobuhiko Furuya | Zendy; Akira Ohno | Zendy; Yoshikazu Ishii | Zendy; Yoichi Hirakata | Zendy; Keizo Yamaguchi | Zendy

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Fosfomycin Alters Lipopolysaccharide-Induced Inflammatory Cytokine Production in Mice

Author(s) -

Tetsuya Matsumoto,

Kazuhiro Tateda,

Shuichi Miyazaki,

Nobuhiko Furuya,

Akira Ohno,

Yoshikazu Ishii,

Yoichi Hirakata,

Keizo Yamaguchi

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.3.697

Subject(s) - lipopolysaccharide , cytokine , fosfomycin , tumor necrosis factor alpha , stimulation , inflammation , pharmacology , interleukin , immunology , medicine , biology , endocrinology , antibiotics , microbiology and biotechnology

To determine the mechanisms of immunomodulating action of fosfomycin (FOF), we examined its effect on the production of inflammatory cytokines in mice injected with lipopolysaccharide (LPS). Treatment with FOF significantly lowered the peak serum levels of tumor necrosis factor alpha and interleukin-1β, indicating that FOF alters inflammatory cytokine production after LPS stimulation.

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