Declining Concentrations of Dihydroartemisinin in Plasma during 5-Day Oral Treatment with Artesunate for Falciparum Malaria | Zendy

Nguyen Xuan Khanh | Zendy; Peter J. de Vries | Zendy; Lê Dang Hà | Zendy; Chris J. van Boxtel | Zendy; Richard P. Koopmans | Zendy; Piet A. Kager | Zendy

Open Access

Declining Concentrations of Dihydroartemisinin in Plasma during 5-Day Oral Treatment with Artesunate for Falciparum Malaria

Author(s) -

Nguyen Xuan Khanh,

Peter J. de Vries,

Lê Dang Hà,

Chris J. van Boxtel,

Richard P. Koopmans,

Piet A. Kager

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.3.690

Subject(s) - artesunate , dihydroartemisinin , plasmodium falciparum , malaria , artemisinin , plasma concentration , pharmacology , medicine , pharmacokinetics , chemistry , immunology

Six patients with uncomplicated falciparum malaria received artesunate for 5 days. Plasma concentrations of artesunate and dihydroartemisinin were determined by high-performance liquid chromatography with electrochemical detection. The concentrations of dihydroartemisinin in plasma 2 h after a dose showed a time-dependent decline. Concentrations of artesunate in plasma especially after the last dose, were very low. Despite this, all patients responded with a fast recovery.

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