Penetration of Meropenem in Lung, Bronchial Mucosa, and Pleural Tissues | Zendy

B. Byl | Zendy; Frédérique Jacobs | Zendy; Ingrid Roucloux | Zendy; Philippe de Franquen | Zendy; Mattéo Cappello | Zendy; J.P. Thys | Zendy

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Penetration of Meropenem in Lung, Bronchial Mucosa, and Pleural Tissues

Author(s) -

B. Byl,

Frédérique Jacobs,

Ingrid Roucloux,

Philippe de Franquen,

Mattéo Cappello,

J.P. Thys

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.3.681

Subject(s) - penetration (warfare) , lung , meropenem , medicine , pathology , microbiology and biotechnology , biology , antibiotics , mathematics , antibiotic resistance , operations research

Lung, bronchial mucosa, and pleural tissue samples were obtained from 14 patients undergoing lung surgery 1 to 5 h after administration of 1 g of meropenem. The mean (range) peak concentrations of meropenem were 3.9 (0.2 to 8.2), 6.6 (3.0 to 13.3), and 2.8 (0.6 to 7.8) mg/kg of tissue, respectively, exceeding the MICs at which 90% of isolates are inhibited for most respiratory pathogens.

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