Italian Survey on Comparative Levofloxacin Susceptibility in 334 Clinical Isolates of Pseudomonas aeruginosa | Zendy

Bernardetta Segatore | Zendy; Domenico Setacci | Zendy; Mariagrazia Perilli | Zendy; Nicola Franceschini | Zendy; Annalisa De Santis | Zendy; Federico Marchetti | Zendy; Gianfranco Amicosante | Zendy

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Italian Survey on Comparative Levofloxacin Susceptibility in 334 Clinical Isolates of Pseudomonas aeruginosa

Author(s) -

Bernardetta Segatore,

Domenico Setacci,

Mariagrazia Perilli,

Nicola Franceschini,

Annalisa De Santis,

Federico Marchetti,

Gianfranco Amicosante

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.428

Subject(s) - levofloxacin , pseudomonas aeruginosa , microbiology and biotechnology , biology , ofloxacin , antibiotics , ciprofloxacin , bacteria , genetics

A national survey on susceptibility patterns of 334 Pseudomonas aeruginosa isolates from intensive care units and hematology and oncology wards from 13 Italian hospitals compared the in vitro activity of levofloxacin, an injectable oral fluoroquinolone, to those of ciprofloxacin, ofloxacin, ceftazidime, imipenem, amikacin, and gentamicin. Amikacin and imipenem had the best susceptibility profiles. The activity of levofloxacin was superior to those of the other quinolones and was comparable to that of ceftazidime. The effect of levofloxacin in vitro on P. aeruginosa clinical isolates suggests that further clinical investigations are warranted.

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