Expression in Escherichia coli of a New Multidrug Efflux Pump, MexXY, from Pseudomonas aeruginosa | Zendy

Tomoyuki Mine | Zendy; Yuji Morita | Zendy; Atsuko Kataoka | Zendy; Tohru Mizushima | Zendy; Tomofusa Tsuchiya | Zendy

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Expression in Escherichia coli of a New Multidrug Efflux Pump, MexXY, from Pseudomonas aeruginosa

Author(s) -

Tomoyuki Mine,

Yuji Morita,

Atsuko Kataoka,

Tohru Mizushima,

Tomofusa Tsuchiya

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.415

Subject(s) - efflux , pseudomonas aeruginosa , escherichia coli , microbiology and biotechnology , plasmid , multiple drug resistance , biology , enterobacteriaceae , antibacterial agent , drug resistance , chemistry , gene , antibiotics , bacteria , genetics

Two new genes (mexXY) similar to mexAB, mexCD, and mexEF and mediating multidrug resistance were cloned from the chromosome of Pseudomonas aeruginosa. Elevated ethidium extrusion was observed with Escherichia coli cells harboring the plasmid carrying mexXY. This MexXY system confers higher resistance to fluoroquinolones than the MexAB and MexCD systems, and E. coli ToIC or P. aeruginosa OprM is necessary for the function of the MexXY system.

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