An Alternative Animal Model for Comparison of Treatments for Cryptococcal Meningitis | Zendy

Laura K. Najvar | Zendy; Rosie Bocanegra | Zendy; John R. Graybill | Zendy

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An Alternative Animal Model for Comparison of Treatments for Cryptococcal Meningitis

Author(s) -

Laura K. Najvar,

Rosie Bocanegra,

John R. Graybill

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.413

Subject(s) - weanling , cryptococcus neoformans , cryptococcal meningitis , meningitis , biology , antifungal , microbiology and biotechnology , animal model , cryptococcosis , medicine , immunology , human immunodeficiency virus (hiv) , surgery , viral disease , endocrinology

Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are an acceptable model for the study of central nervous system infection with C. neoformans.

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