Interplay between Chromosomal β-Lactamase and the MexAB-OprM Efflux System in Intrinsic Resistance to β-Lactams in Pseudomonas aeruginosa | Zendy

Nobuhisa Masuda | Zendy; Naomasa Gotoh | Zendy; Chie Ishii | Zendy; Eiko Sakagawa | Zendy; Satoshi Ohya | Zendy; Takeshi Nishino | Zendy

Open Access

Interplay between Chromosomal β-Lactamase and the MexAB-OprM Efflux System in Intrinsic Resistance to β-Lactams in Pseudomonas aeruginosa

Author(s) -

Nobuhisa Masuda,

Naomasa Gotoh,

Chie Ishii,

Eiko Sakagawa,

Satoshi Ohya,

Takeshi Nishino

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.400

Subject(s) - efflux , pseudomonas aeruginosa , microbiology and biotechnology , mutant , pseudomonadales , pseudomonadaceae , biology , chemistry , bacteria , gene , genetics

We investigated the role of chromosomal β-lactamase and the MexAB-OprM efflux system in intrinsic resistance to β-lactams inPseudomonas aeruginosa . Determination of the susceptibilities of a series of isogenic mutants with impaired production of the β-lactamase and the efflux system to 16 β-lactams including penicillins, cephems, oxacephems, carbapenems, and a monobactam demonstrated that the intrinsic resistance ofP. aeruginosa to most of the β-lactams is due to the interplay of both factors.

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