Resistance of Pseudomonas aeruginosa to Imipenem Induced by Eluates from Siliconized Latex Urinary Catheters Is Related to Outer Membrane Protein Alterations | Zendy

Luis MartínezMartínez | Zendy; Álvaro Pascual | Zendy; Marı́a del Carmen Conejo | Zendy; Leandro Picabea | Zendy; Evelio J. Perea | Zendy

Open Access

Resistance of Pseudomonas aeruginosa to Imipenem Induced by Eluates from Siliconized Latex Urinary Catheters Is Related to Outer Membrane Protein Alterations

Author(s) -

Luis MartínezMartínez,

Álvaro Pascual,

Marı́a del Carmen Conejo,

Leandro Picabea,

Evelio J. Perea

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.397

Subject(s) - imipenem , pseudomonas aeruginosa , microbiology and biotechnology , bacterial outer membrane , pseudomonadaceae , pseudomonadales , membrane , chemistry , membrane protein , bacteria , biology , biochemistry , escherichia coli , gene , genetics

The activity of imipenem against Pseudomonas aeruginosa HUS-3 decreased by 16 times in the presence of substances eluted from siliconized latex urinary catheters (SLUCs). SLUCs did not inactivate imipenem or increase beta-lactamase activity. The outer membrane of P. aeruginosa HUS-3 grown in the presence of eluate lacked an OprD-like protein and expressed a new 50-kDa protein. The decreased activity of imipenem against P. aeruginosa in the presence of SLUCs is related to the loss of an OprD-like protein and the expression of a new outer membrane protein.

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