Activity of a Heat-Induced Reformulation of Amphotericin B Deoxycholate (Fungizone) against Leishmania donovani | Zendy

C. Petit | Zendy; Vanessa Yardley | Zendy; François Gaboriau | Zendy; Jacques Bolard | Zendy; Simon L. Croft | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Activity of a Heat-Induced Reformulation of Amphotericin B Deoxycholate (Fungizone) against Leishmania donovani

Author(s) -

C. Petit,

Vanessa Yardley,

François Gaboriau,

Jacques Bolard,

Simon L. Croft

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.390

Subject(s) - leishmania donovani , amphotericin b , amphotericin b deoxycholate , toxicity , pharmacology , microbiology and biotechnology , leishmania , biology , chemistry , leishmaniasis , antifungal , medicine , immunology , visceral leishmaniasis , parasite hosting , caspofungin , world wide web , computer science

The heat treatment of amphotericin B deoxycholate (Fungizone), which was previously shown to induce superaggregation and decrease the toxicity of the drug to mammalian cells, increased its activity against Leishmania donovani in BALB/c mice, whereas it reduced its toxicity. Heat treatment preserved the activity of Fungizone against L. donovani HU3-infected mouse peritoneal macrophages.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research