Efflux Pump-Mediated Quinolone Resistance in Staphylococcus aureus Strains Wild Type for gyrA , gyrB , grlA , and norA | Zendy

Juan Luis Muñoz Bellido | Zendy; Miguel Manzanares | Zendy; Jonathan Andrés | Zendy; Ma Nieves Gutiérrez Zufiaurre | Zendy; G. Aparicio Ortiz | Zendy; M. Segovia Hernández | Zendy; J A García-Rodríguez | Zendy

Open Access

Efflux Pump-Mediated Quinolone Resistance in Staphylococcus aureus Strains Wild Type for gyrA , gyrB , grlA , and norA

Author(s) -

Juan Luis Muñoz Bellido,

Miguel Manzanares,

Jonathan Andrés,

Ma Nieves Gutiérrez Zufiaurre,

G. Aparicio Ortiz,

M. Segovia Hernández,

J A García-Rodríguez

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.2.354

Subject(s) - efflux , staphylococcus aureus , quinolone , microbiology and biotechnology , ciprofloxacin , biology , antibacterial agent , antibiotics , bacteria , chemistry , genetics

Fluoroquinolone efflux was studied in 47Staphylococcus aureus clinical strains with MICs of ciprofloxacin (CFX) of ≤2 μg/ml. Forty-three strains were wild type forgyrA ,gyrB , andgrlA quinolone resistance-determining regions and fornorA and its promoter region. Forty of these strains (MICs of CFX, 0.1 to 0.2 μg/ml) did not show efflux of fluoroquinolones. Three strains (MICs of CFX, 1 to 2 μg/ml) showed efflux. These results suggest that efflux can appear inS. aureus clinical strains in the absence of mutations innorA and its promoter.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research