Characterization of a Mycobacterium smegmatis Mutant Lacking Penicillin Binding Protein 1 | Zendy

Helen BillmanJacobe | Zendy; Ruth Haites | Zendy; Ross L. Coppel | Zendy

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Characterization of a Mycobacterium smegmatis Mutant Lacking Penicillin Binding Protein 1

Author(s) -

Helen BillmanJacobe,

Ruth Haites,

Ross L. Coppel

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.12.3011

Subject(s) - mycobacterium smegmatis , penicillin binding proteins , mutant , mycobacterium tuberculosis , microbiology and biotechnology , mycobacterium leprae , penicillin , transposable element , biology , antibiotics , gene , chemistry , biochemistry , tuberculosis , medicine , leprosy , pathology , immunology

The ponA gene of Mycobacterium smegmatis encodes a 95-kDa penicillin binding protein, PBP1, that is similar to PBP1s of Mycobacterium tuberculosis and Mycobacterium leprae. Transposon disruption of ponA in M. smegmatis resulted in a PBP1-deficient mutant that was sensitive to beta-lactam antibiotics, was more permeable to glycine, and grew slowly in liquid culture.

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