Open AccessComparative In Vitro Antimicrobial Activities of the Newly Synthesized Quinolone HSR-903, Sitafloxacin (DU-6859a), Gatifloxacin (AM-1155), and Levofloxacin against Mycobacterium tuberculosis and Mycobacterium avium Complex
Author(s) -
Haruaki Tomioka,
Katsumasa Sato,
Tatsuya Akaki,
Hiroko Kajitani,
Shin Kawahara,
Mitsunori Sakatani
Publication year - 1999
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.43.12.3001
Subject(s) - gatifloxacin , levofloxacin , antimycobacterial , mycobacterium kansasii , mycobacterium tuberculosis , microbiology and biotechnology , quinolone , tuberculosis , mycobacterium , ofloxacin , ciprofloxacin , antimicrobial , medicine , antibacterial agent , antibiotics , biology , pathology
We compared the in vitro antimycobacterial activity of a new fluoroquinolone, HSR-903, with strong activity against gram-positive cocci with those of levofloxacin (LVFX), sitafloxacin (STFX), and gatifloxacin (GFLX). The MICs of the quinolones forMycobacterium tuberculosis andMycobacterium avium complex were in the order STFX ≈ GFLX < LVFX ≦ HSR-903 and STFX ≦ GFLX ≦ HSR-903 ≦ LVFX, respectively. HSR-903 effectively eliminated intramacrophagialM. tuberculosis , as did LVFX, and exhibited bacteriostatic effects againstM. tuberculosis replicating in type II alveolar cells.
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