Azithromycin Activities against Orientia tsutsugamushi Strains Isolated in Cases of Scrub Typhus in Northern Thailand | Zendy

George Watt | Zendy; Pacharee Kantipong | Zendy; Krisada Jongsakul | Zendy; Pochaman Watcharapichat | Zendy; Duangporn Phulsuksombati | Zendy

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Azithromycin Activities against Orientia tsutsugamushi Strains Isolated in Cases of Scrub Typhus in Northern Thailand

Author(s) -

George Watt,

Pacharee Kantipong,

Krisada Jongsakul,

Pochaman Watcharapichat,

Duangporn Phulsuksombati

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.11.2817

Subject(s) - orientia tsutsugamushi , scrub typhus , azithromycin , doxycycline , rickettsiosis , medicine , antibacterial agent , virology , microbiology and biotechnology , antibiotics , biology , rickettsia , virus

Azithromycin was given to mice and humans infected with strains of Orientia tsutsugamushi from northern Thailand, where drug-resistant scrub typhus occurs. Azithromycin and doxycycline yielded comparable mouse survival rates (73 and 79%, respectively; P > 0.5). Symptoms, signs, and fever in two pregnant women abated rapidly with azithromycin. Prospective human trials are needed.

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