Synergy Testing of Vancomycin-Resistant Enterococcus faecium against Quinupristin-Dalfopristin in Combination with Other Antimicrobial Agents | Zendy

S. O. Matsumura | Zendy; Lisa Louie | Zendy; Marie Louie | Zendy; A. E. Simor | Zendy

Open Access

Synergy Testing of Vancomycin-Resistant Enterococcus faecium against Quinupristin-Dalfopristin in Combination with Other Antimicrobial Agents

Author(s) -

S. O. Matsumura,

Lisa Louie,

Marie Louie,

A. E. Simor

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.11.2776

Subject(s) - quinupristin , dalfopristin , enterococcus faecium , virginiamycin , microbiology and biotechnology , antimicrobial , vancomycin , enterococcus , antibacterial agent , biology , antibiotics , staphylococcus aureus , bacteria , genetics

Using checkerboard and time-kill assays, we evaluated the in vitro activity of quinupristin-dalfopristin (RP 59500) alone and in combination with five other antimicrobial agents against 12 clinical strains of vancomycin-resistant Enterococcus faecium (VREF). In time-kill studies, six VREF strains exhibited synergism with the combination of quinupristin-dalfopristin and doxycycline and three exhibited synergism with quinupristin-dalfopristin plus ampicillin-sulbactam. Combinations of quinupristin-dalfopristin with these and other agents warrant further clinical evaluation for the treatment of serious VREF infections.

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