Pharmacokinetics of Isepamicin during Continuous Venovenous Hemodiafiltration | Zendy

Dominique Breilh | Zendy; Bernard Allaouchiche | Zendy; H. Jaumain | Zendy; P Boulétreau | Zendy; D. Chassard | Zendy; Isabelle Malbec | Zendy; Dominique Ducint | Zendy; MarieClaude Saux | Zendy

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Pharmacokinetics of Isepamicin during Continuous Venovenous Hemodiafiltration

Author(s) -

Dominique Breilh,

Bernard Allaouchiche,

H. Jaumain,

P Boulétreau,

D. Chassard,

Isabelle Malbec,

Dominique Ducint,

MarieClaude Saux

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.10.2409

Subject(s) - pharmacokinetics , liter , volume of distribution , medicine , elimination rate constant , half life , anesthesia , chemistry , pharmacology

The objective of this study was to analyze the pharmacokinetics of isepamicin during continuous venovenous hemodiafiltration. Six patients received 15 mg of isepamicin per kg of body weight. The mean isepamicin concentration peak in serum was 62.88 +/- 18.20 mg/liter 0.5 h after the infusion. The elimination half-life was 7. 91 +/- 0.83 h. The mean total body clearance was 1.75 +/- 0.28 liters/h, and dialysate outlet (DO) clearance was 2.76 +/- 0.59 liters/h. The mean volume of distribution was 19.83 +/- 2.95 liters. The elimination half-life, DO clearance, and volume of distribution were almost constant. In this group of patients, the initial dosage of 15 mg/kg appeared to be adequate, but the dosage interval should be determined by monitoring residual isepamicin concentrations in plasma.

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