Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae | Zendy

Martin J. Gill | Zendy; N. Brenwald | Zendy; Richard Wise | Zendy

Open Access

Identification of an Efflux Pump Gene, pmrA , Associated with Fluoroquinolone Resistance in Streptococcus pneumoniae

Author(s) -

Martin J. Gill,

N. Brenwald,

Richard Wise

Publication year - 1999

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.43.1.187

Subject(s) - efflux , streptococcus pneumoniae , microbiology and biotechnology , open reading frame , biology , reversion , major facilitator superfamily , antibacterial agent , gene , peptide sequence , phenotype , genetics , antibiotics , mutant

An open reading frame (ORF) homologous tonorA was insertionally inactivated withcat in a fluoroquinolone-resistant pneumococcus with an efflux phenotype; this inactivation caused reversion to drug sensitivity. The ORF product has 24% amino acid sequence identity each to NorA and Bmr, which suggests that it is a major facilitator system pump of the 12-transmembrane-segment class.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research